Ji Mo, a vampire who became immortal centuries ago, lives a quiet life as a biology professor. His life changes when he meets Ruan Tang, who resembles a witch from his past. When a zombie virus leaks from a lab, he protects Ruan, who falls for him despite his vampire nature. To save Ruan's life, Ji Mo sacrifices his own, triggering the return of the witch's powers in Ruan. Faced with a choice to kill Ji Mo for an antidote to save humanity, Ji Mo willingly ends his own life.