Ethan Hayes, sole heir to the Medical Saint, descends to fulfill a marriage contract. At the Jacobs family's banquet, he is humiliated and the contract torn. In rage, he seals the patriarch's meridians. Ethan learns his sister, Joy Hayes, disappeared, and the Jacobs family and Victor Shaw are the masterminds. Armed with medical skills and martial arts, he makes a comeback, sweeping enemies, uncovering conspiracy, to find his sister and settle all debts.