"Dead Girl Walking Route 66" is an apocalyptic road-trip black comedy. After the end of the world, 22-year-old Ava Quinn, a girl with severe social anxiety, hides alone in her home. When she runs out of food and has no way left to survive, she makes a crazy decision—to voluntarily become a zombie. She discovers that after turning into a zombie, she not only no longer feels pain and no longer fears being bitten, but can also understand what other zombies are saying. So she picks up a travel backpack she has never actually used, brings a camera, and sets off on her dream Route 66 road trip: traveling, taking photos, and preferably falling in love.
Along the way, Ava considers herself a "good zombie." She walks through hordes of zombies, takes photos at landmarks, buckles zombies into a raft for a water park ride, throws a midnight radio party to save a human squad, and repeatedly has run-ins with human ability captain Ethan Reed. Ethan once personally buried her, yet while investigating a series of "mysterious help," he gradually recognizes this special zombie who can talk, saves people, and yet has a combat power of only 8.
During the journey, Ava meets and takes in Noah, a seventeen-year-old high-level zombie boy; Benji, a mysterious young child at Level Five or above; and Luna, a "zombie queen" who can command tens of thousands of zombies.
