Tess, a monitor hiding her identity as the Zombie Matriarch, wakes up from a hangover to find she has accidentally spent the night with Rhett, the human race’s most powerful epidemic prevention commander. Her malicious roommate Fallon seizes the chance to impersonate Tess and pose as Rhett’s "fated one", then colludes with the villain Judith to frame and persecute Tess at every turn. After surviving a near-fatal car crash and a deadly poisoning, Rhett finally recognizes his true love, and does not hesitate to undergo a blood exchange to save the dying Tess. In the end, the two publicly execute the vicious villainess at a mobilization rally. Tess, in her true form as the Matriarch, controls the zombie hordes to save the base, and joins forces with Rhett as a power couple to forge the century-old legend of peaceful coexistence between humans and the infected.
