A top CIA agent known as "Ghost" is captured by the head of the Summer family, who attempts to extract her blood, which is believed to possess life‑extending properties. After Ghost kills everyone in her escape, she gets into a car accident and awakens to find herself reincarnated as Cleo, an ugly, low‑status girl at an ultra‑luxurious private high school in New York. The original Cleo was not only bullied by the children of wealthy tycoons at school, but also abused at home by her foster mother Irene and her stepsister Vivian. After taking over the body, Cleo quickly fights back. She uses her extraordinary medical skills to cure her younger brother Ethan's muteness, and while investigating the Summer family—the masterminds behind the experiments performed on her years ago—she meets Tim, the hidden power behind Wall Street. In the end, at a family recognition banquet, she sets a perfect trap, exposing Harrison and his family's crimes to the public and bringing justice for the dozens of lives they destroyed.
