Scarlett Russell, a moderately well-known illustrator, suddenly finds herself drugged and locked in an underground warehouse alongside Anthony Moreno, the CEO of Moreno Pharmaceuticals. High-definition cameras are recording their every move in real-time, broadcasting the feed to "the wealthy" on the dark web for their twisted entertainment.
The streamers have titled this "show" How Long Can They Last? The audience is placing frantic bets, eagerly awaiting the moment these two human specimens—known for being "aloof" and "ascetic"—finally break down. As hallucinogenic and aphrodisiac drugs course through their veins, Scarlett and Anthony must fight not only against their own primal instincts but also against the streamers' increasingly depraved and escalating challenges.
