Virologist Yvonne Roth sacrificed herself, detonating the quarantine zone to eliminate the Mutant Entity, protecting humanity and her young son. She was reborn 70 years later, inhabiting an 18-year-old outcast girl's body. Her son is now the elderly, ill head of the Ji family, holding humanity's fate. Her two great-grandsons are at the core of the Safe Zone. Armed with past life knowledge and devotion, Yvonne sheds her outcast identity, rising to protect her bloodline and humanity.