Jesse, a talented pharmaceutical engineer, loses his job, wealth and girlfriend all at once. Struck by a fatal disease with only three months to live and his parents critically ill in the ICU, he hits rock bottom. He then finds methamphetamine can hold back his sickness and boost his strength.
Having nothing to lose, Jesse uses his science knowledge to seek revenge. Together with his loyal partner Thiago, he builds a drug empire, outwitting drug dealers, gangs, corrupt cops and politicians. He rises from a broken man to the terrifying underworld king of Blackstone City.
His power soon crosses the border. He fights powerful cartels and a crooked general, catching the eye of the U.S. military. The former vulnerable engineer becomes a cold-blooded crime boss, set on protecting his family, avenging himself and destroying all his enemies.
