Jack Mercer, a retired scout, makes a living driving a beat-up heavy truck along the "Dust Storm Corridor", just to save up for surgery for his younger sister who fell into a coma after having her kidney removed. Victor, the second-in-command of a mafia gang, offers him 300,000 US dollars to escort his granddaughter Sophie across the corridor to the border to join her uncle Marcus. A rough man who only cares about money, and a spoiled yet stubborn rich girl, bicker all the way as they hit the road: fake couple kidnapping, scorpion sting, motorcycle gang pursuit, cliff leap, black market bounty in a lawless town... Jack pulls Sophie back from the gates of hell again and again, and Sophie also learns to shoot to save people. Just as the border is within sight, Jack spots the black snake tattoo on Marcus's driver's arm — the exact symbol of the criminal syndicate that destroyed his sister. The so-called pickup is a hit job. The two turn around and fight back, upending the entire conspiracy on the desert highway. When the dust storm clears, the delivery driver becomes hers.
