Ringo Garza, a bottom-tier pizza delivery driver, works desperately to save his seriously ill younger sister. After being bitten by a genetically engineered chameleon from Genesis Corporation, he awakens invisibility, X-ray vision, adhesive wall-crawling, and sonic-boom-launched heavy punches. Through street racing, he meets Olivia, a female mob boss, and becomes her driver and bodyguard. From then on, he effortlessly crushes mobsters, mutant assassins, and mad-scientist tycoons, exposes William—the female boss’s cousin—for colluding with Genesis, destroys a biochemical base, rescues his sister, and becomes the hero of New York—— “Chameleon Man”！
