Zhang Chen, an eighteen-year-old Taoist master of senior seniority, was entrusted by the elder Su Yaozu to protect Su Yuyan, his granddaughter afflicted with the Nine-Yin Cold Constitution. Su Yuyan is persecuted by her clan elders in collusion with the Tang Clan. Her mother is held hostage, and the ancestral divine medicine formula is coveted by enemies. Zhang Chen defeats numerous ancient martial arts experts and breaks the monopoly of the medical alliance. He revises the prescription to create affordable life-saving divine medicine. Tormented by innate Yang Fire Poison, he needs the power of the Nine-Yin Constitution to neutralize it. Along the way, he meets several women suffering from cold poisons. While shielding Su Yuyan and her mother, he practices medicine to help the needy, rooting out villains in business and martial circles, and embarks on a journey of cultivation and salvation.
