Modern medical genius Serena Sutton accidentally travels through time after a car accident and takes over the body of a lazy rural woman, also named Serena Sutton. She begins an ancient life with the hunter Caleb Landon and his two children, practicing medicine to save people, building a fortune, helping Caleb Landon win battles to defend their country, and falling in love with him. The family of four eventually goes into seclusion, traveling the world and providing medical aid to those in need.